Classification of Neurodegenerative Diseases using Machine Learning Methods

Authors

  • Fatih Aydin
  • Zafer Aslan Computer Engineering, Faculty of Engineering, Istanbul Aydin University

DOI:

https://doi.org/10.18201/ijisae.2017526689

Keywords:

Neurodegenerative diseases, Machine Learning, K* classifier, Dimension Reduction, Principal Component Analysis

Abstract

In this study, neurodegenerative diseases (Amyotrophic Lateral Sclerosis, Huntington’s disease, and Parkinson’s disease) were diagnosed and classified using force signals.  In the classification, five machine learning algorithms (Averaged 2-Dependence Estimators (A2DE), K* (K star), Multilayer Perceptron (MLP), Diverse Ensemble Creation by Oppositional Relabeling of Artificial Training Examples (DECORATE), Random Forest) were compared by the 10-fold Cross Validation method. K* classifier gave the best outcome among these algorithms. As a result of quad classification of the K* classifier, the best classification accuracy was 99.17%. According to the first three and five principal component qualifications which are created from these 19 features, the best classification accuracies of K* classifier were 95.44% and 96.68% respectively.

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References

Kaynak Selekler (2010). Alois alzheimer ve alzheimer hastalığı. Türk Geriatri Dergisi. Vol. 13. Pages. 9 14.

Nadire Özaras and Selim Yalçın (2002). Normal yürüme ve yürüme analizi. Turkish Journal of Physical Medicine and Rehabilitation. Vol. 48(3).

National Collaborating Centre for Chronic Conditions (2006). Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care. London, UK: Royal College of Physicians.

Jeffrey M. Bronstein, Michele Tagliati, Ron L. Alterman, Andres M. Lozano, Jens Volkmann, Alessandro Stefani, Fay B. Horak, Michael S. Okun, Kelly D. Foote, Paul Krack, Rajesh Pahwa, Jaimie M. Henderson, Marwan I. Hariz, Roy A. Bakay, Ali Rezai, William J. Marks, Elena Moro, Jerrold L. Vitek, Frances M. Weaver, Robert E. Gross and Mahlon R. DeLong (2011). Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch. Neurol. Vol. 68 (2). Pages. 165.

Samuel Frank and Joseph Jankovic (2010). Advances in the pharmacological management of huntington's disease. Drugs. Vol. 70(5). Pages. 561 571.

Patrick Russell and Roger Harrison (2014). What is amyotrophic lateral sclerosis?. Clinical Pharmacist. Vol. 6(7).

Masood Banaie, Mohammad Pooyan and Mohammad Mikaili (2011). Introduction and application of an automatic gait recognition method to diagnose movement disorders that arose of similar causes. Expert Systems with Applications. Vol. 38(6). Pages. 7359 7363.

Mohammad R. Daliri (2012). Automatic diagnosis of neuro-degenerative diseases using gait dynamics. Measurement. Vol. 45(7). Pages. 1729 1734.

Sang-Hong Lee and Joon S. Lim (2012). Parkinson’s disease classification using gait characteristics and wavelet-based feature extraction. Expert Systems with Applications. Vol. 39(8). Pages. 7338 7344.

Yi Xia, Qingwei Gao and Qiang Ye (2015). Classification of gait rhythm signals between patients withneuro-degenerative diseases and normal subjects: Experiments withstatistical features and different classification models. Biomedical Signal Processing and Control. Vol. 18. Pages. 254 262.

PhysioNET. Gait Dynamics in Neuro-Degenerative Disease Data Base. http://www.physionet.org/physiobank/database/gaitndd/. [Accessed: 13.04.2015].

Jeffrey M. Hausdorff, Zvi Ladin and Jeanne Y. Wei (1995). Footswitch system for measurement of the temporal parameters of gait. J Biomech. Vol. 28(3). Pages. 347–351.

Jeffrey M. Hausdorff, Susan L. Mitchell, Renee Firtion, Chung-Kang Peng, Merit E. Cudkowicz, Jeanne Y. Wei and Ary L. Goldberger (1997). Altered fractal dynamics of gait: reduced stride-interval correlations with aging and huntington's disease. J Applied Physiology. Vol. 82(1). Pages. 262-269.

Jeffrey M. Hausdorff, Apinya Lertratanakul, Merit E. Cudkowicz, Amie L. Peterson, David Kaliton and Ary L. Goldberger (2000). Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis. J Applied Physiology. Vol. 88. Pages. 2045-2053.

Pamela K. Douglas, Sam Harris, Alan L. Yuille and Mark S. Cohen (2011). Performance comparison of machine learning algorithms and number of independent components used in fMRI decoding of belief vs. disbelief. NeuroImage. Vol. 56(2). Pages. 544 553.

Ian H. Witten and Eibe Frank (2005). Data Mining: Practical Machine Learning Tools and Techniques. 2nd ed. San Francisco, CA, USA: Morgan Kaufmann.

Stuart J. Russell and Peter Norvig (2003). Artificial Intelligence: A Modern Approach. 2nd ed. Upper Saddle River, New Jersey, USA: Prentice Hall.

Pedro Domingos (2000). A unifed bias-variance decomposition and its applications, In: Proceedings of the Seventeenth International Conference on Machine Learning, 29 June-2 July 2000; Stanford, CA, USA. San Francisco, CA, USA: Morgan Kaufmann. pp. 231-238.

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Published

31.03.2017

How to Cite

Aydin, F., & Aslan, Z. (2017). Classification of Neurodegenerative Diseases using Machine Learning Methods. International Journal of Intelligent Systems and Applications in Engineering, 5(1), 1–9. https://doi.org/10.18201/ijisae.2017526689

Issue

Section

Research Article