Synthesis And Biological Evaluation of Fluoroluminescent Ruthenium Complexes as Potential Cancer Therapeutics
Keywords:
pBR322DNA, calf thymus DNA, cytotoxic, BMPIP, polypyridyl complexes, Absorption, emission, viscosity, photocleavage, anciliary, Intercalating.Abstract
Ruthenium (II) polypyridyl complexes are one of the most extensively studied and developed systems in the family of luminescent transition-metal complexes. There has been a large amount of interest in the biological applications of these luminescent ruthenium (II) complexes because of their rich photo physical and photochemical properties with a focus on their use as phototherapeutic agents. A new ligand BMPIP (2-(3-methoxy-4 phenoxy phenyl)-1-H-imidazo[4,5-f][1,10]phenantroline) and its four luminescent ruthenium complexes were synthesized and characterized DNA binding studies, photo cleavage studies, anti microbial studies were performed and the cytotoxic activity of the complexes against cancer HeLa cells was evaluated by MTT method. The IC50 values range from 41 ± 0.5 to 62 ± 0.5 μM. Photodynamic therapy (PDT) has recently emerged as a potential valuable alternative to treat microbial infections. In PDT, singlet oxygen is generated in the presence of photo sensitizers and oxygen under light irradiation of a specific wavelength, causing cytotoxic damage to bacteria. However, both complexes exhibit lower cytotoxicity than cisplatin toward HeLa cell lines under identical conditions.
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I. Ali, W.A.Wani, K.Saleem, Cancer scenario in India with future perspectives , Cancer Ther. 8 (2011) 56-70
I. Ali, Rahis-Uddin, K. Saleem, H.Y. Aboul-Enein, A. Rather, Cancer Ther. 8 (2011) 6-14.
B. Rosenberg, L. Van Camp, J. E. Trosko, V. H. Mansour, , Nature. 222 (1969) 385.
E. R. Jamieson , S. J. Lippard, Chem. Rev. 99 (1999) 2467- .
(a) L. Xu, Y. Y. Liu, L. M. Chen, Y.Y. Xie, J. X. Liang, H. Chao, J. Inorg. Biochem. 2016, 159, 82. (b) T. S. Kamatchi, P. Kalaivani, F. R. Fronczek, K. Natarajan, R. Prabhakaran, RSC Adv. 2016, 6, 46531.
(a) Y. Zhang, P. C. Hu, P. Cai, F. Yang, G. Z. Cheng, RSC Adv. 5 2015, 11591. (b) M. M. Milutinovic, A. Rilak, I. Bratsos, O. Klisuric, M. Vranes, N. Gligorijevic, S. Radulovic, Z. D. Bugarcic, J. Inorg. Biochem. 2017, 169, 1. N. J. Wheate, J. G. Collins, Coord. Chem. Rev. 241 (2003) 133.
C. X. Zhang , S. J. Lippard, Curr. Opin. Chem. Biol. 7 (2003) 481.
L. R. Kelland, S. Y. Sharp, Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs. 1 (1999) 380.
V. Ravi Kumar, D. Kamakshi, Y. Praveen Kumar, M. Vinoda Rani, M. Rajender Reddy, Ch. Nagamani, Ch. Ravi, S. Suman Thakur, Ch. Mohan Rao, S.Satyanarayana, New. J. Chem. 2018, 42, 846.
B. Tang, D. Wan, S. H. Lai, H. H. Yang, C. Zhang, X. Z. Wang, C. C. Zeng, Y. J. Liua, J. of Inorg. Biochem. 2017, 173, 93.
A. Bergamo, G. Sava, Dalton Trans. (2007)1267−1272.
A.Bergamo, A.Masi, A.F.A. Peacock, A.Habtemariam, P.J. Sadler, G.Sava, J. Inorg. Biochem. 104 (2010) 79−86.
W.H. Ang, A. Casini, G. Sava, P.J. Dyson, J.Organomet. Chem. 696 ( 2011) 989−998
V. Ravi Kumar, D. Kamakshi, Y. Praveen Kumar, M. Vinoda Rani, M. Rajender Reddy, Ch. Nagamani, Ch. Ravi, S. Suman Thakur, Ch. Mohan Rao, S. Satyanarayana, New J. Chem.2018, 42, 846.
(a) J. Chen, Y. Zhang, G. Li, F. Peng, X. Jie, J. She, G. Dongye, Z. Zou, S. Rong, L. Chen , J. Bioinorg. Chem. 2017, 1528. (b) B. Tang, D. Wan, S-H. Lai, H-H. Yang, C.Zhang, X-Z. Wang, C-C. Zeng, Y-Y. Liu, J. Inorg. Biochem. 2017, 173, 93.
(a) C. Mari, R. Rubbani, G. Gasser, Inorg. Chimi. Acta, 2017, 454, 21. (b) F. Heinemann, J. Karges, G. Gasser, Acc. Chem. Res. 2017, 50, 2727
M. . Gill, H. Derrat, C.G. Smythe, G. Battaglia, J.A.Thomas, ChemBioChem 12 (6) (2011) 877−880.
M. R. Gill, J.A.Thomas, Chem. Soc. Rev. 41 (8) (2012) 3179−3192.
F. R. Svensson, J. Andersson, H.L. Amand, P.J. Lincoln, Biol. Inorg. Chem. 17 (4) (2012) 565−571.
O.Zava, S. M. Zakeeruddin, C. Danelon, H. Vogel, M. Gratzel, P. J. Dyson, ChemBioChem. 10 (11) (2009) 1796−1800.
C.A.Puckett, J. K. Barton, J. Am. Chem. Soc. 129 (1) (2007) 46−47.
C.A.Puckett, . J. K. Barton, Biochemistry, 47 (45) (2008) 11711−11716.
C.A.Puckett, . J. K. Barton, J. Am. Chem. Soc. 131 (25) (2009) 8738−8739.
C.A.Puckett, . J. K. Barton, Puckett, Bioorg. Med. Chem. 18 (10) (2010) 3564−3569.
C.A.Puckett, . R. J. Emst, J. K. Barton, Dalton Trans. 39 (5) (2010) 1159−1170.
A. Juris, V. Balzani, F.Barigelletti, S.Campagna, P. Belser, A. Vonzelewsky, Coord. Chem. Rev. 84 (1988) 85−277.
C. Tan, S. Lai, S. Wu, S. Hu, L. Zhou, Y. Chen, M. Wang, Y. Zhu, W. Lian, W. Peng, L. Ji, A. Xu, J. Med. Chem. 53 (2010) 7613-7624.
H.L. Huang, Z.Z. Li, Z.H. Liang, Y.J. Liu, Eur. J. Inorg. Chem. 36 (2011) 5538-5547.
H.J. Yu, Y. Chn, L. Yu, Zhi-fenghao, L.H. Zhou, Eur. J. Med. Chem. 55 (2012) 146-154
C.P Tan, S.H. Wu, S.S. Lai, M.X. Wang, Y. Chen, L.J. Zhou, Y.P. Zhu. W.L. Peng, L.N. Ji, A.L. Xu, Dalton Trans. 40 (2011) 8611-8621
X-W. Liu, Y. Xiao, W-G. Peng, L-J. Zhao, Y-M. Shen, S-B. Zhang, J. L. Lu, Applied Organo Metal Chemistry, 2018, 4231.
W. X. Hong, F. Huang, T. Huan, Xu Xu , Q. Han, G. Wang, H. Xua, S. Duan, Y. Duan, X. Long, Y. Liu, Z. Hu, J. of Inorg. Biochem. 2018, 180, 54.
C. Shobha Devi, D. Anil Kumar, Surya S Singh, NazarGabra, N. Deepika, Y. Praveen Kumar, S. Satyanarayana, Eur. J. Med. Chem. 64 (2013) 410-421
N. Deepika, Y. Praveen Kumar, C. Shobha, P. Venkat Reddy, A. Srishailam, S. Satyanarayana, J. Biol. Inorg. Chem. 18 (2013) 751-766.
A. Srishailam, Y. Praveen Kumar, P. Venkat Reddy, G. Md. Nazar, N.Navaneetha, V.Uma, Surya S Singh, S. Satyanarayana, J. Photochem. Photobiol. B ; Biol. 132, (2014) 111-123.
C. Shobha Devi, P. Nagababu, N.Sumathi, N. Deepika, P. Venkat Reddy, N. Veerababu, Surya S Singh , S. Satyanarayana, Eur. J. Med. Chem. 72 (2014) 160-169.
A. Srishailam, G. Md. Nazar, Y. Praveen Kumar, K.Laxma Reddy, C. Shobha Devi, D.Anil Kumar, Surya S Singh, S. Satyanarayana, J. Photochem. Photobiol. B.;.Biol. 141 (2014) 47-58.
P.Venkat Reddy, M. Rajender Reddy, A. Srishailam, Y. Praveen Kumar, Ch. Nagamani, N. Deepika, K. Nagasuryaprasad, Surya S Sing , S. Satyanarayana, Analytical Biochemistry, 485 (2015) 49-58
M. Yamada, Y. Tanaka, Y. Yoshimoto, S. Kuroda, I. Shimao,BullChem.Soc. Jpn. 65 (1992) 2007–2009
B.P.Sullivan, D.J. Sullivan, B.P. Salmon , T.J. Mayer, Inorg. Chem. 17(1978) 3334–3341
A. Wolfe, G. H Shimer Jr, T. Meehan Biochemistry, 26 (1987) 6392.
J.D.Mc Ghee and P.H. Hippel J. Mol.Bol.,86 (1974) 469.
G.Cohen, H. Eisenberg, Biopolymers, 8 (1969) 45.
S. Satyanarayana, J.C. Dabrowiak, J.B. Chaires, Biochemistry 32 (1993) 2573–2584
Z. Darzynkiewicz, Methods Cell Biol. 33 (1990) 285–298
W. Gorczyca, M.A. Hotz, P. Lassota, F. Traganos, Cytometry, 13 (1992) 795–808
S.N. Farrow, R. Brown, Curr. Opin. Genet. Dev., 6 (1996) 45.
T.J. Mosmann, J. Immunol Methods,65 (1983) 45.
Vilar, S.; Cozza, G.; Moro, S. Curr. Top. Med. Chem., 8 (2008) 1555.
C.Zhao,H.Lin, S.Zhu, H.Sun, Y.Chen, J Inorg. Biochem. 70(1998)219-226.
M.Howe-Grant, K.C. Wu, W.R.Bauer, S.J.Lippart, Biochemistry, 15 (1976)4339-4346.
S. Satyanarayana, J.C. Dabrowiak, J.B. Chaires. Biochemistry., 32 (1993) 2573.
S. Satyanarayana, J.C. Dabrrowiak, J.B. Chaires, Biochemistry, , 31 (1992) 9319.
Vilar, S.; Cozza, G.; Moro, S. Curr. Top. Med. Chem. 8 (2008) 1555.
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