Engineering Resilient Supply Chains for Critical Healthcare Manufacturing During Global Disruptions
Keywords:
Supply Chain Resilience, Healthcare Manufacturing, Disruption Management, Predictive Risk Analytics, Supplier Diversification, Production ContinuityAbstract
Healthcare manufacturing supply chains are the operating system for global public health systems. Recent disruptions have shown that existing lean systems, which are designed to be most efficient, are not strong enough to handle simultaneous increases in demand, supplier backlog, regulatory constraints, and logistics constraints all at the same time. These limitations expose structural flaws in current supply chains. This article considers the structural characteristics and behavior of supply chain resilience in healthcare manufacture and reviews approaches to supply chain structural failure modes, supplier network optimization, predictive risk analytics, and integrated production continuity. A Resilient Manufacturing Network Framework synthesizing supply chain engineering and real-time analytics is proposed to enable proactive and reactive disruption management. This article demonstrates that resilience cannot be achieved through any single intervention in the supply chain landscape but instead requires the coordinated deployment of diversified supplier architectures, anticipatory risk intelligence, responsive production planning systems, and a shared digital backbone.
Downloads
References
Fu Jia et al., "Triple A supply chain management and sustainability," Industrial Management & Data Systems 125, no. 10 (2025): 2725–2752. Available: https://doi.org/10.1108/IMDS-10-2023-0756
Dmitry Ivanov and Alexandre Dolgui, "A digital supply chain twin for managing the disruption risks and resilience in the era of Industry 4.0," Production Planning & Control 32, no. 9 (2021): 775–788. Available: https://www.tandfonline.com/action/showCitFormats?doi=10.1080/09537287.2020.1768450
European Medicines Agency, "Good manufacturing practice." (n.d.). Available: https://www.ema.europa.eu/en/human-regulatory-overview/research-development/compliance-research-development/good-manufacturing-practice
World Health Organization, "Global surveillance and monitoring system for substandard and falsified medical products: activity report, August 2017–December 2021," 2024. Available: https://www.who.int/publications/i/item/9789240097513
Vikas Kumar et al., "Artificial intelligence applications in healthcare supply chain networks under disaster conditions," International Journal of Production Research 63, no. 2 (2025): 395–403. Available: https://www.tandfonline.com/doi/pdf/10.1080/00207543.2024.2444150
David Simchi-Levi et al., "Supply Chain Competition and Collaboration Models," in The Logic of Logistics: Theory, Algorithms, and Applications for Logistics Management, pp. 213–228. New York, NY: Springer New York, 2013. Available: https://link.springer.com/chapter/10.1007/978-1-4614-9149-1_11
Martin Christopher and Helen Peck, "Building the resilient supply chain," International Journal of Logistics Management, 2004. Available: https://dspace.lib.cranfield.ac.uk/server/api/core/bitstreams/6ce1ceca-e8c6-4b37-8f26-6fdbe3c08a8a/content
Sunil Chopra and M. S. Sodhi, "Supply-chain breakdown," MIT Sloan Management Review 46, no. 1 (2004): 53–61. Available: https://d1wqtxts1xzle7.cloudfront.net/34808711/Supply_chain_Break_down-libre.pdf
Thomas H. Davenport and Rajeev Ronanki, "Artificial intelligence for the real world," Harvard Business Review 96, no. 1 (2018): 108–116. Available: https://academichelptoday.com/assets/documents/Artificial_Intelligence_for_the_Real_World_-_HBR.pdf
Maciel M. Queiroz et al., "Impacts of epidemic outbreaks on supply chains: mapping a research agenda amid the COVID-19 pandemic through a structured literature review," Annals of Operations Research 319, no. 1 (2022): 1159–1196. Available: https://link.springer.com/content/pdf/10.1007/s10479-020-03685-7.pdf
Paul H. Zipkin, “Foundations of Inventory Management,” New York: McGraw Hill, 2000. Available: https://sutlib2.sut.ac.th/sut_contents/H105195.pdf
Steven Nahmias, "Perishable inventory theory: A review," Operations Research 30, no. 4 (1982): 680–708. Available: https://www.researchgate.net/profile/Steven-Nahmias/publication/12999281_Perishable_Inventory_Theory_A_Review
Michael L. Pinedo, "Design and implementation of scheduling systems: More advanced concepts," in Scheduling: Theory, Algorithms, and Systems, pp. 485–508. Cham: Springer International Publishing, 2016. Available: https://link.springer.com/chapter/10.1007/978-3-319-26580-3_18
Elaine Dezenski, "Building supply chain resilience," World Economic Forum, 2012. Available: https://www.weforum.org/stories/2012/09/building-supply-chain-resilience/
United Nations, "The Sustainable Development Goals Report 2022," 2022. Available: https://unstats.un.org/sdgs/report/2022/
McKinsey Global Institute, "Risk, resilience, and rebalancing in global value chains," 2020. Available: https://www.mckinsey.com/~/media/mckinsey/business%20functions/operations/our%20insights/risk-resilience-and-rebalancing-in-global-value-chains-full-report-vh.pdf
U.S. Food and Drug Administration, "Drug Supply Chain Security Act (DSCSA)," 2025. Available: https://www.fda.gov/drugs/drug-supply-chain-integrity/drug-supply-chain-security-act-dscsa
Oluwadare Badejo and Marianthi Ierapetritou, "Enhancing pharmaceutical supply chain resilience: A multi-objective study with disruption management," Computers & Chemical Engineering 188 (2024): 108769. Available: https://www.sciencedirect.com/science/article/abs/pii/S009813542400187X
Claudia Piffari et al., "Challenges in Healthcare Supply Chain Resilience Management: A Conceptual Framework," IFAC-Papers On Line 58, no. 19 (2024): 1126–1131. Available: https://www.sciencedirect.com/science/article/pii/S2405896324015246
Pankaj Bhardwaj et al., "Resilience in Public Healthcare Supply Chain Management: A Scoping Review from Indian Perspective," DY Patil Journal of Health Sciences 13, no. 2 (2025): 89–95. Available: https://journals.lww.com/dypj/fulltext/2025/04000/resilience_in_public_healthcare_supply_chain.1.aspx
Mustafa Alfaouri et al., "Pharmaceutical supply chain management challenges in developing countries: a systematic literature review," Journal of African Business 26, no. 4 (2025): 798–841. Available: https://www.tandfonline.com/doi/pdf/10.1080/15228916.2025.2532943
C. López et al., "Modeling supply chain disruptions due to geopolitical reasons: A systematic literature review," Transportation Research Part E: Logistics and Transportation Review 202 (2025): 104290. Available: https://www.sciencedirect.com/science/article/pii/S136655452500331X
U.S. Department of Health and Human Services, "Defining and Measuring the Resilience, Criticality, and Vulnerability of Medical Product Supply Chains," 2025. Available: https://aspe.hhs.gov/reports/measuring-supply-chain-resilience
Raji Ramakrishnan Nair et al., "Predictive BlockVax distribution: Enhancing healthcare supply chain resilience with blockchain and LSTM," International Journal of Computational Intelligence Systems 18, no. 1 (2025): 159. Available: https://link.springer.com/content/pdf/10.1007/s44196-025-00897-2.pdf
ManMohan S. Sodhi and Christopher S. Tang, "Managing Supply Chain Risk," Springer International Publishing, 2012. Available: https://doi.org/10.1007/978-1-4614-3238-8
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.
IJISAE open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.
